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CMU-60 template

Introduction
The CMU-60 template is an averaged map of reconstructed fiber orientations from a 257-direction diffusion spectrum imaging (DSI) sequence from 60 neurologically healthy volunteers. The files are in DSI Studio format, which is free to download here. This dataset includes the original 30 subjects from the CMU-30 template (found here).
These data sets are free to use for research and education purposes. Please notify Dr. Verstynen should they be used in a conference abstract or publication.

The original download link is at http://www.psy.cmu.edu/~coaxlab/data.html#cmu60

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Participants
Twenty nine male and thirty one female subjects were recruited from the local Pittsburgh community and the Army Research Laboratory in Aberdeen Maryland. All subjects were neurologically healthy, with no history of either head trauma or neurological or psychiatric illness. Subject ages ranged from 18 to 45 years of age at the time of scanning, with a mean age of 26 years (+/- 6 standard deviation). Six subjects were left handed (3 males, 3 females).

Acquisition
All participants were scanned on a Siemen’s Verio 3T system in the Scientific Imaging & Brain Research (SIBR) Center at Carnegie Mellon University using a 32-channel head coil. We collected a 50 min, 257-direction DSI scan using a twice-refocused spin-echo EPI sequence and multiple q values (TR = 9,916 ms, TE = 157 ms, voxel size = 2.4 x 2.4 x 2.4 mm, FoV = 231 x 231 mm, b-max = 5,000 s/mm2, 51 slices). Head-movement was minimized during the image acquisition through padding supports and all subjects were confirmed to have minimal head movement during the can prior to inclusion in the template.

Processing
All images were processed using a q-space diffeomorphic reconstruction method described previously (Yeh & Tseng, 2011). Briefly, this approach uses a non-linear coregistration approach (ICBM-152 space template regularization, 16 non-linear iterations) that registers the voxel-coordinate into MNI space while also maintaining distortion of the q-space vector during the normalization process. From here diffusion orientation distribution functions (dODFs) are reconstructed to spatial resolution of 2x2x2 mm. The final template image was created by averaging the ODF maps across all 60 subjects, and the resulting template can be used to obtain the representative tractography of the. The white matter surface is rendered independently from an externally supplied 1×1×1 mm resolution white matter image.

Reference
Yeh FC, Tseng WY. NTU-90: a high angular resolution brain atlas constructed by q-space diffeomorphic reconstruction. Neuroimage. 2011 Sep 1;58(1):91-9

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