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Local connectome fingerprints of the Human Connectome Project (HCP) 1065 subjects

Introduction

Local connectome fingerprints (LCF)[1] provide a unified quantification of brain connections in a standard space at the voxel level. The concept is similar to "DNA profiling", which gives a unique pattern for individuals' genomic characteristics without sequencing the entire genome. LCF does not map the entire connectome either. The local connectome is the brain connection (the global connectome) breaking down into small elements at the voxel level, allowing us to study their connectivity from a piece-wise perspective. The connectivity of the local axonal connection can be quantified by their density of diffusing water calculated from the diffusion MRI signals. The quantification of LCF does not rely on fiber tracking or tracing.

This is very different from commonly used connectomic approach, which maps region-to-region connectivity as the basic unit of the brain connectivity, and fiber tracking or fiber tracing play important roles.


Why LCF?
Fiber tracking methods or axonal tracing techniques have limitation in resolution and accuracy. Diffusion MRI fiber tracking is known to be sensitive to parameters and tends to give a substantial amount of false connections. The error accumulates along with the tracking and tracing process, and often time the results can be highly sensitive to both systematic and experimental error. Any quantitative measurement based on fiber tracking or tracing thus inherits the variability and the test-retest reliability of the results are usually not very high. In comparison, DNA profiling has a high test-retest reliability with a miss identification rate of 1 over billions. The uniqueness achieved by fMRI or dMRI connectome connectivity is around 1%~10% shown from the connectome fingerprint studies [1][2].

LCF aims to bypass this limitation by directly quantifying the connectivity using the density of diffusing water measured from the diffusion MRI signals. Our study showed that LCF has a uniqueness at 10-6 using 2.5 mm dMRI data sets [1].

Data set

The following link provides MATLAB MAT files storing the LCF of the HCP 1065 subjects at 1-mm resolution. These MAT files store LCF vectors of the HCP 1065 subjects (vectors from subject0 to subject 1064). The dimension matrix gives the dimension of the standard space. The MNI matrix stores the MNI coordinate of each LCF entry. The fiber orientation matrix stores the local axonal direction of each LCF entry. The subject ID of these 1065 subjects are stored in the subject id text file.

Box space: Download link

The these three files are the LCF at 1 mm. 
HCP1056.1mm.db.fib.gz.vec0.mat
HCP1056.1mm.db.fib.gz.vec1.mat
HCP1056.1mm.db.fib.gz.vec2.mat

The these three files are the LCF at 2 mm. 
HCP1056.2mm.db.fib.gz.vec0.mat
HCP1056.2mm.db.fib.gz.vec1.mat
HCP1056.2mm.db.fib.gz.vec2.mat


Citations
[1] Yeh F-C, Vettel JM, Singh A, Poczos B, Grafton ST, Erickson KI, et al. (2016) Quantifying Differences and Similarities in Whole-Brain White Matter Architecture Using Local Connectome Fingerprints. PLoS Comput Biol 12(11): e1005203. https://doi.org/10.1371/journal.pcbi.1005203
[2] Finn, Emily S., Xilin Shen, Dustin Scheinost, Monica D. Rosenberg, Jessica Huang, Marvin M. Chun, Xenophon Papademetris, and R. Todd Constable. "Functional connectome fingerprinting: identifying individuals using patterns of brain connectivity." Nature neuroscience 18, no. 11 (2015): 1664-1671.

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